Identity
HGNC
LOCATION
2q34
LOCUSID
ALIAS
ALS19,HER4,p180erbB4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2066
MIM: 600543
HGNC: 3432
Ensembl: ENSG00000178568
Variants:
dbSNP: 2066
ClinVar: 2066
TCGA: ENSG00000178568
COSMIC: ERBB4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131301952 | gefitinib | Chemical | Pathway | associated | |||
| PA134687924 | erlotinib | Chemical | Pathway | associated | |||
| PA152241907 | lapatinib | Chemical | Pathway | associated | |||
| PA163518919 | paliperidone | Chemical | MultilinkAnnotation | associated | 25714000 | ||
| PA29988 | JAK1 | Gene | Pathway | associated | |||
| PA33308 | PIK3CA | Gene | Pathway | associated | |||
| PA33309 | PIK3CB | Gene | Pathway | associated | |||
| PA33310 | PIK3CD | Gene | Pathway | associated | |||
| PA33311 | PIK3CG | Gene | Pathway | associated | |||
| PA33312 | PIK3R1 | Gene | Pathway | associated | |||
| PA33313 | PIK3R2 | Gene | Pathway | associated | |||
| PA33314 | PIK3R3 | Gene | Pathway | associated | |||
| PA33392 | PLCG1 | Gene | Pathway | associated | |||
| PA33393 | PLCG2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37870708 | 2024 | Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan. | 0 |
| 38369520 | 2024 | Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer. | 2 |
| 37870708 | 2024 | Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan. | 0 |
| 38369520 | 2024 | Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer. | 2 |
| 36584483 | 2023 | Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy. | 1 |
| 37196148 | 2023 | miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4. | 2 |
| 37290686 | 2023 | MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4. | 1 |
| 37369570 | 2023 | NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders. | 3 |
| 38063127 | 2023 | ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression. | 1 |
| 38149095 | 2023 | Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study. | 1 |
| 36584483 | 2023 | Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy. | 1 |
| 37196148 | 2023 | miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4. | 2 |
| 37290686 | 2023 | MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4. | 1 |
| 37369570 | 2023 | NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders. | 3 |
| 38063127 | 2023 | ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression. | 1 |
Citation
Dessen P
ERBB4 (erb-b2 receptor tyrosine kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40480/erbb4
