Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9156
MIM: 606063
HGNC: 3511
Ensembl: ENSG00000174371
Variants:
dbSNP: 9156
ClinVar: 9156
TCGA: ENSG00000174371
COSMIC: EXO1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445058 | Neoplasm Metastasis | Disease | ClinicalAnnotation | associated | PD | ||
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38126949 | 2024 | Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-β1/Smad signaling feedback loop. | 0 |
| 38266640 | 2024 | EXO1 protects BRCA1-deficient cells against toxic DNA lesions. | 4 |
| 38279172 | 2024 | EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression. | 0 |
| 38721777 | 2024 | EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. | 0 |
| 38126949 | 2024 | Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-β1/Smad signaling feedback loop. | 0 |
| 38266640 | 2024 | EXO1 protects BRCA1-deficient cells against toxic DNA lesions. | 4 |
| 38279172 | 2024 | EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression. | 0 |
| 38721777 | 2024 | EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. | 0 |
| 36693839 | 2023 | A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene. | 4 |
| 36735534 | 2023 | PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1. | 2 |
| 36971680 | 2023 | Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma. | 1 |
| 37140056 | 2023 | MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1. | 5 |
| 37227155 | 2023 | The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression. | 1 |
| 36693839 | 2023 | A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene. | 4 |
| 36735534 | 2023 | PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1. | 2 |
Citation
Dessen P
EXO1 (exonuclease 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40512/exo1
