F2 (coagulation factor II, thrombin)

2003-06-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
PT,RPRGL2,THPH1
FUSION GENES

Other Information

Locus ID:

NCBI: 2147
MIM: 176930
HGNC: 3535
Ensembl: ENSG00000180210

Variants:

dbSNP: 2147
ClinVar: 2147
TCGA: ENSG00000180210
COSMIC: F2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180210ENST00000311907P00734
ENSG00000180210ENST00000442468C9JV37
ENSG00000180210ENST00000530231E9PIT3

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Regulation of actin cytoskeletonKEGGko04810
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Regulation of actin cytoskeletonKEGGhsa04810
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsREACTOMER-HSA-159854
Gamma-carboxylation of protein precursorsREACTOMER-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusREACTOMER-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteinsREACTOMER-HSA-159782
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166179849avatrombopagChemicalLabelAnnotationassociated
PA166182748lusutrombopagChemicalLabelAnnotationassociated
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA28660GGCXGenePathwayassociated
PA446969Venous ThrombosisDiseaseClinicalAnnotationassociatedPD12069454, 15208046, 16769590, 28750087
PA447054StrokeDiseaseClinicalAnnotationassociatedPD12069454, 15208046, 16769590, 28750087
PA451581tamoxifenChemicalLabelAnnotationassociated
PA452637hormonal contraceptives for systemic useChemicalClinicalAnnotationassociatedPD12069454, 15208046, 16769590, 28750087

References

Pubmed IDYearTitleCitations
193620882009Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.168
172083412007Thrombin generation and fibrin clot structure.145
145234512003Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120700202002Thrombin functions during tissue factor-induced blood coagulation.79
155341752004Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.78
196360032009D-dimer and prothrombin fragment 1 + 2 predict venous thromboembolism in patients with cancer: results from the Vienna Cancer and Thrombosis Study.76
165808982006Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.74
157697472005Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling.73
203512332010Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model.70

Citation

Dessen P

F2 (coagulation factor II, thrombin)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40520/f2-