F2 (coagulation factor II, thrombin)

2003-06-01  

Identity

HGNC
F2
LOCATION
11p11.2
LOCUSID
2147
ALIAS
PT,RPRGL2,THPH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2147
MIM: 176930
HGNC: 3535
Ensembl: ENSG00000180210

Variants:

dbSNP: 2147
ClinVar: 2147
TCGA: ENSG00000180210
COSMIC: F2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180210ENST00000311907P00734
ENSG00000180210ENST00000442468C9JV37
ENSG00000180210ENST00000530231E9PIT3

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Regulation of actin cytoskeletonKEGGko04810
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Regulation of actin cytoskeletonKEGGhsa04810
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsREACTOMER-HSA-159854
Gamma-carboxylation of protein precursorsREACTOMER-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusREACTOMER-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteinsREACTOMER-HSA-159782
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166179849avatrombopagChemicalLabelAnnotationassociated
PA166182748lusutrombopagChemicalLabelAnnotationassociated
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA28660GGCXGenePathwayassociated
PA446969Venous ThrombosisDiseaseClinicalAnnotationassociatedPD12069454, 15208046, 16769590, 28750087
PA447054StrokeDiseaseClinicalAnnotationassociatedPD12069454, 15208046, 16769590, 28750087
PA451581tamoxifenChemicalLabelAnnotationassociated
PA452637hormonal contraceptives for systemic useChemicalClinicalAnnotationassociatedPD12069454, 15208046, 16769590, 28750087

References

Pubmed IDYearTitleCitations
379189712024Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties.1
379843592024The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System.1
381640892024Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway.0
381745612024Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.1
383974672024Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen.1
379189712024Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties.1
379843592024The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System.1
381640892024Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway.0
381745612024Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.1
383974672024Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen.1
367245092023Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.0
367587262023Intraindividual variability over time of thrombin generation in patients with cirrhosis.1
370441322023Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients.1
370461892023Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis.1
371129182023Inflammatory Response and Activation of Coagulation after COVID-19 Infection.5

Citation

Dessen P

F2 (coagulation factor II, thrombin)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40520/gene-fusions-explorer/js/gene-explorer/