F3 (coagulation factor III, tissue factor)

2003-08-01  

Identity

HGNC
F3
LOCATION
1p21.3
LOCUSID
2152
ALIAS
CD142,TF,TFA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2152
MIM: 134390
HGNC: 3541
Ensembl: ENSG00000117525

Variants:

dbSNP: 2152
ClinVar: 2152
TCGA: ENSG00000117525
COSMIC: F3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117525ENST00000334047P13726
ENSG00000117525ENST00000370207P13726

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Extrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140834
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446459Myocardial IschemiaDiseaseClinicalAnnotationassociatedPD19027114
PA451363simvastatinChemicalClinicalAnnotationassociatedPD19027114

References

Pubmed IDYearTitleCitations
372015352024Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.0
381916732024Tissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer.1
372015352024Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.0
381916732024Tissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer.1
366961802023Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease.10
369802512023The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.1
372631222023Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis.5
373777512023CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation.3
375113442023High CD142 Level Marks Tumor-Promoting Fibroblasts with Targeting Potential in Colorectal Cancer.1
375836992023Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis.1
375891382023Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.0
380692092023Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19.1
366961802023Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease.10
369802512023The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.1
372631222023Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis.5

Citation

Dessen P

F3 (coagulation factor III, tissue factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40522