FBL (fibrillarin)

2003-11-01  

Identity

HGNC
FBL
LOCATION
19q13.2
LOCUSID
2091
ALIAS
FIB,FLRN,Nop1,RNU3IP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2091
MIM: 134795
HGNC: 3599
Ensembl: ENSG00000105202

Variants:

dbSNP: 2091
ClinVar: 2091
TCGA: ENSG00000105202
COSMIC: FBL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105202ENST00000221801P22087
ENSG00000105202ENST00000594309M0R2B0
ENSG00000105202ENST00000594443M0QXC9
ENSG00000105202ENST00000595545M0R299
ENSG00000105202ENST00000597224M0QXL5
ENSG00000105202ENST00000597634M0R0P1
ENSG00000105202ENST00000598417M0R1H0
ENSG00000105202ENST00000599134M0R2U2
ENSG00000105202ENST00000601274M0R2Q4

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369286412023Current research on viral proteins that interact with fibrillarin.3
374896172023FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.3
369286412023Current research on viral proteins that interact with fibrillarin.3
374896172023FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.3
335225702021Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin.6
337958752021A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation.43
335225702021Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin.6
337958752021A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation.43
320118312020Analysis of the rRNA methylation complex components in pediatric B-cell precursor acute lymphoblastic leukemia: A pilot study.9
323846862020Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.10
320118312020Analysis of the rRNA methylation complex components in pediatric B-cell precursor acute lymphoblastic leukemia: A pilot study.9
323846862020Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.10
301904782018Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance.30
305409302018SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle.38
301904782018Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance.30

Citation

Dessen P

FBL (fibrillarin)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40539