KDM2A (lysine demethylase 2A)

2003-08-01  

Identity

HGNC
KDM2A
LOCATION
11q13.2
LOCUSID
22992
ALIAS
CXXC8,FBL11,FBL7,FBXL11,JHDM1A,LILINA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22992
MIM: 605657
HGNC: 13606
Ensembl: ENSG00000173120

Variants:

dbSNP: 22992
ClinVar: 22992
TCGA: ENSG00000173120
COSMIC: KDM2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173120ENST00000308783I3VM54
ENSG00000173120ENST00000398645Q9Y2K7
ENSG00000173120ENST00000529006Q9Y2K7
ENSG00000173120ENST00000529006I3VM53
ENSG00000173120ENST00000530342Q9Y2K7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378455852024Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.1
378455852024Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.1
367239502023Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance.2
369910192023Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance.3
373110542023Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.1
377511352023Biological Functions of the KDM2 Family of Histone Demethylases.1
367239502023Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance.2
369910192023Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance.3
373110542023Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.1
377511352023Biological Functions of the KDM2 Family of Histone Demethylases.1
355374492022NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.14
356976782022Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3.6
359325802022KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma.0
360845472022Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro.1
355374492022NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.14

Citation

Dessen P

KDM2A (lysine demethylase 2A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40540/img/js/haematological-explorer/