FER (FER tyrosine kinase)

2003-02-01 Affiliation

Identity

HGNC

FER

LOCATION

5q21.3

LOCUSID

2241

ALIAS

PPP1R74,TYK3,p94-Fer

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2241
MIM: 176942
HGNC: 3655
Ensembl: ENSG00000151422

Variants:

dbSNP: 2241
ClinVar: 2241
TCGA: ENSG00000151422
COSMIC: FER

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151422	ENST00000281092	P16591
ENSG00000151422	ENST00000281092	W0S0X4
ENSG00000151422	ENST00000438717	W0S4B9
ENSG00000151422	ENST00000504143	D6RAF9
ENSG00000151422	ENST00000618353	P16591
ENSG00000151422	ENST00000628534	A0A0D9SEV4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Adherens junction	KEGG	ko04520
Adherens junction	KEGG	hsa04520
Signal Transduction	REACTOME	R-HSA-162582
Signaling by SCF-KIT	REACTOME	R-HSA-1433557

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35550247	2022	FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.	7
35550247	2022	FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.	7
33411917	2021	Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling.	11
33430475	2021	Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.	5
33806191	2021	Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells.	4
33411917	2021	Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling.	11
33430475	2021	Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.	5
33806191	2021	Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells.	4
29099290	2020	FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer.	7
31746983	2020	FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.	8
29099290	2020	FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer.	7
31746983	2020	FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.	8
29208465	2018	A curvature-dependent membrane binding by tyrosine kinase Fer involves an intrinsically disordered region.	5
29540831	2018	FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion.	17
29907877	2018	Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia.	10

Citation

Dessen P

FER (FER tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40544