FES (FES proto-oncogene, tyrosine kinase)

2003-02-01  

Identity

HGNC
FES
LOCATION
15q26.1
LOCUSID
2242
ALIAS
FPS

Other Information

Locus ID:

NCBI: 2242
MIM: 190030
HGNC: 3657
Ensembl: ENSG00000182511

Variants:

dbSNP: 2242
ClinVar: 2242
TCGA: ENSG00000182511
COSMIC: FES

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182511ENST00000328850P07332
ENSG00000182511ENST00000328850A0A024RC92
ENSG00000182511ENST00000394300P07332
ENSG00000182511ENST00000394302E7ENM8
ENSG00000182511ENST00000414248P07332
ENSG00000182511ENST00000416779C9J3W6
ENSG00000182511ENST00000443697E9PGC7
ENSG00000182511ENST00000444422P07332
ENSG00000182511ENST00000452243E7EMJ7
ENSG00000182511ENST00000464684E9PIJ7
ENSG00000182511ENST00000470152H0YNT6
ENSG00000182511ENST00000559355H0YNN8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363214462022The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.12
363214462022The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.12
315739552020Identification of FES as a Novel Radiosensitizing Target in Human Cancers.2
317469832020FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.8
315739552020Identification of FES as a Novel Radiosensitizing Target in Human Cancers.2
317469832020FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.8
234045072013A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.11
234045072013A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.11
198651122010Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.45
201170792010FES kinase participates in KIT-ligand induced chemotaxis.2
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
198651122010Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.45
201170792010FES kinase participates in KIT-ligand induced chemotaxis.2
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
190010852009Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.13

Citation

Dessen P

FES (FES proto-oncogene, tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40546