ARHGEF10L (Rho guanine nucleotide exchange factor 10 like)

2003-05-01  

Identity

HGNC
ARHGEF10L
LOCATION
1p36.13
LOCUSID
55160
ALIAS
GrinchGEF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55160
MIM: 612494
HGNC: 25540
Ensembl: ENSG00000074964

Variants:

dbSNP: 55160
ClinVar: 55160
TCGA: ENSG00000074964
COSMIC: ARHGEF10L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074964ENST00000167825A0A384DVK7
ENSG00000074964ENST00000361221Q9HCE6
ENSG00000074964ENST00000375408Q5VXI4
ENSG00000074964ENST00000375415Q9HCE6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
321547662020ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.3
321547662020ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.3
304449692019ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.8
304449692019ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.8
299797932018Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.8
299797932018Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.8
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.0
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.0
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
188499932008Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.60
188499932008Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.60
161120812005GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.10
161120812005GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.10

Citation

Dessen P

ARHGEF10L (Rho guanine nucleotide exchange factor 10 like)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40584/haematological-explorer/css/js/template.js