NSUN2 (NOP2/Sun RNA methyltransferase 2)

2003-12-01  

Identity

HGNC
NSUN2
LOCATION
5p15.31
LOCUSID
54888
ALIAS
MISU,MRT5,SAKI,TRM4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54888
MIM: 610916
HGNC: 25994
Ensembl: ENSG00000037474

Variants:

dbSNP: 54888
ClinVar: 54888
TCGA: ENSG00000037474
COSMIC: NSUN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000037474ENST00000264670Q08J23
ENSG00000037474ENST00000504374A0A140T9Y7
ENSG00000037474ENST00000506139Q08J23
ENSG00000037474ENST00000514127A0A140T9Z1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382377382024NSUN2-Mediated m(5)C Methylation Impairs Endometrial Receptivity.0
383876872024LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1.0
3840325020245-Methylcytosine transferase NSUN2 drives NRF2-mediated ferroptosis resistance in non-small cell lung cancer.0
384112982024NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m(5)C-dependent manner.0
387640102024NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m(5)C methylation.0
388449632024NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m(5)C methylation.0
382377382024NSUN2-Mediated m(5)C Methylation Impairs Endometrial Receptivity.0
383876872024LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1.0
3840325020245-Methylcytosine transferase NSUN2 drives NRF2-mediated ferroptosis resistance in non-small cell lung cancer.0
384112982024NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m(5)C-dependent manner.0
387640102024NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m(5)C methylation.0
388449632024NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m(5)C methylation.0
361839762023NSUN2-mediated mRNA m(5)C Modification Regulates the Progression of Hepatocellular Carcinoma.9
365293492023NSUN2 gene rs13181449 C>T polymorphism reduces neuroblastoma risk.8
367925872023NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m(5)C methylation.10

Citation

Dessen P

NSUN2 (NOP2/Sun RNA methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40599/cancer-prone-explorer/css/lib/js/web-card-_common.js