VGLL3 (vestigial like family member 3)

2003-06-01  

Identity

HGNC
VGLL3
LOCATION
3p12.1
LOCUSID
389136
ALIAS
VGL-3,VGL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 389136
MIM: 609980
HGNC: 24327
Ensembl: ENSG00000206538

Variants:

dbSNP: 389136
ClinVar: 389136
TCGA: ENSG00000206538
COSMIC: VGLL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000206538ENST00000383698A8MV65
ENSG00000206538ENST00000398399A8MV65
ENSG00000206538ENST00000494229H7C571
ENSG00000206538ENST00000637106A0A1B0GTF5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383487442024Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations.1
383487442024Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations.1
367549612023VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.9
367549612023VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.9
352565552022Clinicopathologic and Molecular Study of Hybrid Nerve Sheath Tumors Reveals Their Common Association With Fusions Involving VGLL3.5
354348222022VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.5
357669972022Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.7
359416752022Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway.5
352565552022Clinicopathologic and Molecular Study of Hybrid Nerve Sheath Tumors Reveals Their Common Association With Fusions Involving VGLL3.5
354348222022VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.5
357669972022Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.7
359416752022Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway.5
336494582021Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.11
346791872021VGLL3 activates inflammatory responses by inducing interleukin-1α secretion.7
336494582021Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.11

Citation

Dessen P

VGLL3 (vestigial like family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40607/case-report-explorer/favicon/tumors-explorer/