FLT3LG (fms related receptor tyrosine kinase 3 ligand)

2003-02-01  

Identity

HGNC
FLT3LG
LOCATION
19q13.33
LOCUSID
2323
ALIAS
FL,FLG3L,FLT3L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2323
MIM: 600007
HGNC: 3766
Ensembl: ENSG00000090554

Variants:

dbSNP: 2323
ClinVar: 2323
TCGA: ENSG00000090554
COSMIC: FLT3LG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090554ENST00000204637P49771
ENSG00000090554ENST00000594009P49771
ENSG00000090554ENST00000595510P49771
ENSG00000090554ENST00000596435M0QYM9
ENSG00000090554ENST00000597551P49771
ENSG00000090554ENST00000597914M0R3A6
ENSG00000090554ENST00000598555M0QXI0
ENSG00000090554ENST00000600084M0R2K0
ENSG00000090554ENST00000600429P49771
ENSG00000090554ENST00000601800M0R2K0

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Hematopoietic cell lineageKEGGhsa04640
Pathways in cancerKEGGhsa05200
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

References

Pubmed IDYearTitleCitations
387017832024FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.0
387017832024FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.0
368450822023Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses.2
368450822023Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses.2
352810042022Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.2
360814952022FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia.0
352810042022Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.2
360814952022FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia.0
333691362021A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia.5
333691362021A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia.5
321553242020Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.5
321553242020Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.5
306309802019FLT3 ligand plasma levels in acute myeloid leukemia.7
310351722019FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia.0
311753122019Mesenchymal stem cell therapy induces FLT3L and CD1c(+) dendritic cells in systemic lupus erythematosus patients.68

Citation

Dessen P

FLT3LG (fms related receptor tyrosine kinase 3 ligand)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40611