FOLR1 (folate receptor alpha)

2003-02-01  

Identity

HGNC
FOLR1
LOCATION
11q13.4
LOCUSID
2348
ALIAS
FBP,FOLR,FRalpha,NCFTD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2348
MIM: 136430
HGNC: 3791
Ensembl: ENSG00000110195

Variants:

dbSNP: 2348
ClinVar: 2348
TCGA: ENSG00000110195
COSMIC: FOLR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110195ENST00000312293P15328
ENSG00000110195ENST00000312293A0A024R5H1
ENSG00000110195ENST00000393676P15328
ENSG00000110195ENST00000393676A0A024R5H1
ENSG00000110195ENST00000393679P15328
ENSG00000110195ENST00000393679A0A024R5H1
ENSG00000110195ENST00000393681P15328
ENSG00000110195ENST00000393681A0A024R5H1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450428methotrexateChemicalPathwayassociated21317831

References

Pubmed IDYearTitleCitations
363960122023Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.2
364028752023Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.15
375065332023Folate receptor alpha is widely expressed and a potential therapeutic target in uterine and ovarian carcinosarcoma.2
378837282023Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.0
380578302023Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1.2
363960122023Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.2
364028752023Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.15
375065332023Folate receptor alpha is widely expressed and a potential therapeutic target in uterine and ovarian carcinosarcoma.2
378837282023Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.0
380578302023Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1.2
350949172022Emerging roles for folate receptor FOLR1 in signaling and cancer.26
355453632022Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.0
362452302022High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer.2
364265472022High Expression of Folate Receptor Alpha (FOLR1) is Associated With Aggressive Tumor Behavior, Poor Response to Chemoradiotherapy, and Worse Survival in Rectal Cancer.4
350949172022Emerging roles for folate receptor FOLR1 in signaling and cancer.26

Citation

Dessen P

FOLR1 (folate receptor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40620