FOSB (FosB proto-oncogene, AP-1 transcription factor subunit)

2003-02-01  

Identity

HGNC
FOSB
LOCATION
19q13.32
LOCUSID
2354
ALIAS
AP-1,G0S3,GOS3,GOSB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2354
MIM: 164772
HGNC: 3797
Ensembl: ENSG00000125740

Variants:

dbSNP: 2354
ClinVar: 2354
TCGA: ENSG00000125740
COSMIC: FOSB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125740ENST00000353609P53539
ENSG00000125740ENST00000353609A0A024R0P6
ENSG00000125740ENST00000417353P53539
ENSG00000125740ENST00000443841P53539
ENSG00000125740ENST00000585836P53539
ENSG00000125740ENST00000586615P53539
ENSG00000125740ENST00000589593K7EKA0
ENSG00000125740ENST00000590335K7EJ89
ENSG00000125740ENST00000591858P53539
ENSG00000125740ENST00000592436K7EKC1
ENSG00000125740ENST00000592811K7ERZ8
ENSG00000125740ENST00000615753P53539

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
374612732024Lack of FOS/FOSB Gene Rearrangements in Ischemic Fasciitis Indicates Distinct Pathogenesis from Proliferative Fasciitis and Proliferative Myositis.0
374612732024Lack of FOS/FOSB Gene Rearrangements in Ischemic Fasciitis Indicates Distinct Pathogenesis from Proliferative Fasciitis and Proliferative Myositis.0
368982762023Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells.3
374783142023NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.2
375532462023New kids on the block: FOS and FOSB gene.1
368982762023Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells.3
374783142023NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.2
375532462023New kids on the block: FOS and FOSB gene.1
359107612022Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation.1
359813632022[The Prognostic Value of FOSB Gene in Acute Myeloid Leukemia].1
360088782022Inflammatory lobular hemangioma (T-cell-rich angiomatoid polypoid pseudolymphoma)-Assessment of FOS/FOSB and lymphoid markers and comparison with epithelioid hemangioma.1
359107612022Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation.1
359813632022[The Prognostic Value of FOSB Gene in Acute Myeloid Leukemia].1
360088782022Inflammatory lobular hemangioma (T-cell-rich angiomatoid polypoid pseudolymphoma)-Assessment of FOS/FOSB and lymphoid markers and comparison with epithelioid hemangioma.1
341536822021Knockout of FosB gene changes drug sensitivity and invasion activity via the regulation of Bcl-2, E-cadherin, β-catenin, and vimentin expression.4

Citation

Dessen P

FOSB (FosB proto-oncogene, AP-1 transcription factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40621/deep-insight-explorer/img/gene-fusions/?id=40621