FOXP2 (forkhead box P2)

2003-05-01  

Identity

HGNC
FOXP2
LOCATION
7q31.1
LOCUSID
93986
ALIAS
CAGH44,SPCH1,TNRC10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 93986
MIM: 605317
HGNC: 13875
Ensembl: ENSG00000128573

Variants:

dbSNP: 93986
ClinVar: 93986
TCGA: ENSG00000128573
COSMIC: FOXP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128573ENST00000350908O15409
ENSG00000128573ENST00000360232O15409
ENSG00000128573ENST00000378237O15409
ENSG00000128573ENST00000390668Q8N6B5
ENSG00000128573ENST00000393489O15409
ENSG00000128573ENST00000393491Q0PRL4
ENSG00000128573ENST00000393494O15409
ENSG00000128573ENST00000393495A8MTU2
ENSG00000128573ENST00000393498A8MUV4
ENSG00000128573ENST00000403559O15409
ENSG00000128573ENST00000408937O15409
ENSG00000128573ENST00000408937X5D2H2
ENSG00000128573ENST00000412402O15409
ENSG00000128573ENST00000440349F8WDL6
ENSG00000128573ENST00000441290O15409
ENSG00000128573ENST00000452963C9JQP8
ENSG00000128573ENST00000462331Q75MZ5
ENSG00000128573ENST00000634411A0A0U1RQR8
ENSG00000128573ENST00000634623A0A0U1RQE0
ENSG00000128573ENST00000635109O15409
ENSG00000128573ENST00000635534A0A0U1RQY3
ENSG00000128573ENST00000635563A0A0U1RQE6
ENSG00000128573ENST00000635638A0A0U1RQM2
ENSG00000128573ENST00000638397A0A1W2PS63

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377136002024FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis.0
384188032024Novel FOXP2 variant associated with speech and language dysfunction in a Chinese family and literature review.0
377136002024FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis.0
384188032024Novel FOXP2 variant associated with speech and language dysfunction in a Chinese family and literature review.0
352797442023Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.4
363284232023In-depth characterisation of a cohort of individuals with missense and loss-of-function variants disrupting FOXP2.10
363317192023Silencing FOXP2 reverses vemurafenib resistance in BRAF(V600E) mutant papillary thyroid cancer and melanoma cells.2
364449382023LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2.0
366177422023Investigation of the forkhead box protein P2 gene by the next-generation sequence analysis method in children diagnosed with specific learning disorder.0
368790292023Functional dissection of two amino acid substitutions unique to the human FOXP2 protein.2
352797442023Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.4
363284232023In-depth characterisation of a cohort of individuals with missense and loss-of-function variants disrupting FOXP2.10
363317192023Silencing FOXP2 reverses vemurafenib resistance in BRAF(V600E) mutant papillary thyroid cancer and melanoma cells.2
364449382023LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2.0
366177422023Investigation of the forkhead box protein P2 gene by the next-generation sequence analysis method in children diagnosed with specific learning disorder.0

Citation

Dessen P

FOXP2 (forkhead box P2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40633