SRSF10 (serine and arginine rich splicing factor 10)

2003-02-01  

Identity

HGNC
SRSF10
LOCATION
1p36.11
LOCUSID
10772
ALIAS
FUSIP1,FUSIP2,NSSR,PPP1R149,SFRS13,SFRS13A,SRp38,SRrp40,TASR,TASR1,TASR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10772
MIM: 605221
HGNC: 16713
Ensembl: ENSG00000188529

Variants:

dbSNP: 10772
ClinVar: 10772
TCGA: ENSG00000188529
COSMIC: SRSF10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188529ENST00000343255O75494
ENSG00000188529ENST00000344989O75494
ENSG00000188529ENST00000374452O75494
ENSG00000188529ENST00000374453Q5JRI1
ENSG00000188529ENST00000453840O75494
ENSG00000188529ENST00000473858R4GMP8
ENSG00000188529ENST00000484146O75494
ENSG00000188529ENST00000492112O75494
ENSG00000188529ENST00000492112A0A0S2Z504
ENSG00000188529ENST00000495785Q6IQ42

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381607882024Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma.2
381607882024Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma.2
366456332023lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis.5
366456332023lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis.5
352966592022The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.16
365398372022SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis.4
352966592022The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.16
365398372022SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis.4
333001592021Identification of SRSF10 as a regulator of SMN2 ISS-N1.8
333001592021Identification of SRSF10 as a regulator of SMN2 ISS-N1.8
323386002020Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.13
326003792020SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.33
331808342020Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.23
323386002020Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.13
326003792020SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.33

Citation

Dessen P

SRSF10 (serine and arginine rich splicing factor 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40648/teaching-explorer/deep-insight-explorer/tumors-explorer/