GAK (cyclin G associated kinase)

2003-02-01  

Identity

HGNC
GAK
LOCATION
4p16.3
LOCUSID
2580
ALIAS
DNAJ26,DNAJC26
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2580
MIM: 602052
HGNC: 4113
Ensembl: ENSG00000178950

Variants:

dbSNP: 2580
ClinVar: 2580
TCGA: ENSG00000178950
COSMIC: GAK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178950ENST00000314167O14976
ENSG00000178950ENST00000502656D6RAW3
ENSG00000178950ENST00000504668H0Y9M4
ENSG00000178950ENST00000505819D6RE78
ENSG00000178950ENST00000507580D6RF16
ENSG00000178950ENST00000510799H0YA39
ENSG00000178950ENST00000511163O14976
ENSG00000178950ENST00000511229D6RC24
ENSG00000178950ENST00000511980H0Y8H5
ENSG00000178950ENST00000512325D6RAQ7
ENSG00000178950ENST00000618573A0A087X1U9
ENSG00000178950ENST00000628912D6RE78

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346710152021GAK and PRKCD are positive regulators of PRKN-independent mitophagy.21
346710152021GAK and PRKCD are positive regulators of PRKN-independent mitophagy.21
319623452020Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.20
326625382020Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.5
332085572020Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.11
319623452020Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.20
326625382020Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.5
332085572020Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.11
281359062017GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.3
284727632017LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.20
288297652017RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.8
281359062017GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.3
284727632017LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.20
288297652017RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.8
263184312016Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.4

Citation

Dessen P

GAK (cyclin G associated kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40681