GAS1 (growth arrest specific 1)

2003-02-01  

Identity

HGNC
LOCATION
9q21.33
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 2619
MIM: 139185
HGNC: 4165
Ensembl: ENSG00000180447

Variants:

dbSNP: 2619
ClinVar: 2619
TCGA: ENSG00000180447
COSMIC: GAS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180447ENST00000298743P54826

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Ligand-receptor interactionsREACTOMER-HSA-5632681
Activation of SMOREACTOMER-HSA-5635838

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
347967742022Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog.7
347967742022Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog.7
299419842018Additive effects of the combined expression of soluble forms of GAS1 and PTEN inhibiting glioblastoma growth.10
303275482018Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity.9
299419842018Additive effects of the combined expression of soluble forms of GAS1 and PTEN inhibiting glioblastoma growth.10
303275482018Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity.9
268056872017MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1.13
281849272017Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.6
268056872017MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1.13
281849272017Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.6
262150532016Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells.4
274016112016Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.35
274533372016WT1 is involved in the Akt-JNK pathway dependent autophagy through directly regulating Gas1 expression in human osteosarcoma cells.10
262150532016Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells.4
274016112016Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.35

Citation

Dessen P

GAS1 (growth arrest specific 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40684/gas1