MSTN (myostatin)

2004-02-01  

Identity

HGNC
MSTN
LOCATION
2q32.2
LOCUSID
2660
ALIAS
GDF8,MSLHP

Other Information

Locus ID:

NCBI: 2660
MIM: 601788
HGNC: 4223
Ensembl: ENSG00000138379

Variants:

dbSNP: 2660
ClinVar: 2660
TCGA: ENSG00000138379
COSMIC: MSTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138379ENST00000260950O14793
ENSG00000138379ENST00000260950Q53S46

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376489592024Myostatin expression in lung cancer induces sarcopenia and promotes cancer progression.0
378012032024Skeletal muscle myostatin mRNA expression is upregulated in aged human adults with excess adiposity but is not associated with insulin resistance and ageing.0
380888652024Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.0
383091902024Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.2
376489592024Myostatin expression in lung cancer induces sarcopenia and promotes cancer progression.0
378012032024Skeletal muscle myostatin mRNA expression is upregulated in aged human adults with excess adiposity but is not associated with insulin resistance and ageing.0
380888652024Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.0
383091902024Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.2
365351102023Correlation between lipoprotein(a), albuminuria, myostatin and sarcopenia in elderly patients with type 2 diabetes.2
369018942023Myostatin Overexpression and Smad Pathway in Detrusor Derived from Pediatric Patients with End-Stage Lower Urinary Tract Dysfunction.0
369802392023Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers.4
371431062023Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression.2
377380422023Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells.1
380822522023Genetic variants in myostatin and its receptors promote elite athlete status.2
381172152023Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients.0

Citation

Dessen P

MSTN (myostatin)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/40703/gene-fusions-explorer/gene-explorer/js/lib/jquery-3.5.1.min.js