Identity
HGNC
LOCATION
10q25.3
LOCUSID
ALIAS
GDNFR,GDNFRA,GFR-ALPHA-1,GFRalpha-1,RET1L,RETL1,TRNR1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2674
MIM: 601496
HGNC: 4243
Ensembl: ENSG00000151892
Variants:
dbSNP: 2674
ClinVar: 2674
TCGA: ENSG00000151892
COSMIC: GFRA1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000151892 | ENST00000355422 | P56159 |
| ENSG00000151892 | ENST00000369234 | P56159 |
| ENSG00000151892 | ENST00000369236 | P56159 |
| ENSG00000151892 | ENST00000439649 | P56159 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36768269 | 2023 | The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells. | 1 |
| 36768269 | 2023 | The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells. | 1 |
| 35832649 | 2022 | LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer. | 4 |
| 35832649 | 2022 | LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer. | 4 |
| 33020172 | 2021 | Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis. | 6 |
| 34391932 | 2021 | Deficiency of GFRα1 promotes hepatocellular carcinoma progression but enhances oxaliplatin-mediated anti-tumor efficacy. | 0 |
| 34668628 | 2021 | CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression. | 25 |
| 33020172 | 2021 | Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis. | 6 |
| 34391932 | 2021 | Deficiency of GFRα1 promotes hepatocellular carcinoma progression but enhances oxaliplatin-mediated anti-tumor efficacy. | 0 |
| 34668628 | 2021 | CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression. | 25 |
| 31988584 | 2020 | Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. | 6 |
| 32841458 | 2020 | LncRNA LINC00210 regulated radiosensitivity of osteosarcoma cells via miR-342-3p/GFRA1 axis. | 7 |
| 33175846 | 2020 | Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer. | 4 |
| 33233403 | 2020 | Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells. | 5 |
| 31988584 | 2020 | Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. | 6 |
Citation
Dessen P
GFRA1 (GDNF family receptor alpha 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40708/gfra1
