GHRH (growth hormone releasing hormone)

2003-10-01  

Identity

HGNC
GHRH
LOCATION
20q11.23
LOCUSID
2691
ALIAS
GHRF,GRF,INN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2691
MIM: 139190
HGNC: 4265
Ensembl: ENSG00000118702

Variants:

dbSNP: 2691
ClinVar: 2691
TCGA: ENSG00000118702
COSMIC: GHRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118702ENST00000237527P01286
ENSG00000118702ENST00000373611P01286
ENSG00000118702ENST00000373614P01286

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
355660202022Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variants in Primary Human Endometrial Carcinomas: Novel Therapeutic Approaches.2
355660202022Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variants in Primary Human Endometrial Carcinomas: Novel Therapeutic Approaches.2
320659792020A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility.3
330605642020Structural basis for activation of the growth hormone-releasing hormone receptor.27
320659792020A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility.3
330605642020Structural basis for activation of the growth hormone-releasing hormone receptor.27
294265772018Common variants at somatostatin are significantly associated with hypertension incidence in smoking and drinking populations.0
295715942018Occurrence of neoplasms in individuals with congenital, severe GH deficiency from the Itabaianinha kindred.6
303441242018P53, GHRH, inflammation and cancer.49
294265772018Common variants at somatostatin are significantly associated with hypertension incidence in smoking and drinking populations.0
295715942018Occurrence of neoplasms in individuals with congenital, severe GH deficiency from the Itabaianinha kindred.6
303441242018P53, GHRH, inflammation and cancer.49
281301212017Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth.24
284386142017The expression of GHRH and its receptors in breast carcinomas with apocrine differentiation-further evidence of the presence of a GHRH pathway in these tumors.8
286262142017Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis through growth hormone receptor.1

Citation

Dessen P

GHRH (growth hormone releasing hormone)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/40712