Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2768
MIM: 604394
HGNC: 4380
Ensembl: ENSG00000146535
Variants:
dbSNP: 2768
ClinVar: 2768
TCGA: ENSG00000146535
COSMIC: GNA12
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000146535 | ENST00000275364 | Q03113 |
| ENSG00000146535 | ENST00000407653 | E9PC54 |
| ENSG00000146535 | ENST00000407904 | Q03113 |
| ENSG00000146535 | ENST00000447791 | C9J2Y7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA27946 | F2R | Gene | Pathway | associated | 20938371 | ||
| PA27949 | F2RL3 | Gene | Pathway | associated | 20938371 | ||
| PA32868 | P2RY1 | Gene | Pathway | associated | 20938371 | ||
| PA33384 | PLCB1 | Gene | Pathway | associated | 20938371 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20938371 | ||
| PA348 | TBXA2R | Gene | Pathway | associated | 20938371 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38104152 | 2023 | Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion. | 0 |
| 38104152 | 2023 | Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion. | 0 |
| 35020952 | 2022 | ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12. | 4 |
| 35020952 | 2022 | ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12. | 4 |
| 33386590 | 2021 | Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12. | 11 |
| 33386590 | 2021 | Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12. | 11 |
| 32330601 | 2020 | Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation. | 2 |
| 32778842 | 2020 | G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. | 23 |
| 32330601 | 2020 | Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation. | 2 |
| 32778842 | 2020 | G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. | 23 |
| 28394299 | 2017 | c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells. | 10 |
| 28921504 | 2017 | Gα(12) facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. | 22 |
| 28394299 | 2017 | c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells. | 10 |
| 28921504 | 2017 | Gα(12) facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. | 22 |
| 26632408 | 2016 | Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155. | 7 |
Citation
Dessen P
GNA12 (G protein subunit alpha 12)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40725/gna12
