Identity
HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
GIP,GNAI2B,H_LUCA15.1,H_LUCA16.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2771
MIM: 139360
HGNC: 4385
Ensembl: ENSG00000114353
Variants:
dbSNP: 2771
ClinVar: 2771
TCGA: ENSG00000114353
COSMIC: GNAI2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134971947 | P2RY12 | Gene | Pathway | associated | 20938371 | ||
| PA164741137 | ADCY3 | Gene | Pathway | associated | 20938371 | ||
| PA192 | HTR1A | Gene | Pathway | associated | 19741567 | ||
| PA24560 | ADCY1 | Gene | Pathway | associated | 19741567 | ||
| PA24561 | ADCY2 | Gene | Pathway | associated | 19741567 | ||
| PA24562 | ADCY4 | Gene | Pathway | associated | |||
| PA24563 | ADCY5 | Gene | Pathway | associated | |||
| PA27 | ADCY6 | Gene | Pathway | associated | |||
| PA28 | ADCY7 | Gene | Pathway | associated | |||
| PA29 | ADCY8 | Gene | Pathway | associated | |||
| PA29549 | HTR1B | Gene | Pathway | associated | 19741567 | ||
| PA29550 | HTR1D | Gene | Pathway | associated | 19741567 | ||
| PA29552 | HTR1E | Gene | Pathway | associated | 19741567 | ||
| PA29553 | HTR1F | Gene | Pathway | associated | 19741567 | ||
| PA30 | ADCY9 | Gene | Pathway | associated | |||
| PA34361 | RGS1 | Gene | Pathway | associated | |||
| PA39 | ADRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35115535 | 2022 | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth. | 11 |
| 35115535 | 2022 | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth. | 11 |
| 33531622 | 2021 | Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals. | 10 |
| 34294713 | 2021 | S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. | 24 |
| 34322898 | 2021 | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 4 |
| 34439877 | 2021 | GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. | 7 |
| 33531622 | 2021 | Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals. | 10 |
| 34294713 | 2021 | S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. | 24 |
| 34322898 | 2021 | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 4 |
| 34439877 | 2021 | GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. | 7 |
| 31936673 | 2020 | Preferential Coupling of Dopamine D(2S) and D(2L) Receptor Isoforms with G(i1) and G(i2) Proteins-In Silico Study. | 10 |
| 33308256 | 2020 | The Gαi protein subclass selectivity to the dopamine D(2) receptor is also decided by their location at the cell membrane. | 6 |
| 31936673 | 2020 | Preferential Coupling of Dopamine D(2S) and D(2L) Receptor Isoforms with G(i1) and G(i2) Proteins-In Silico Study. | 10 |
| 33308256 | 2020 | The Gαi protein subclass selectivity to the dopamine D(2) receptor is also decided by their location at the cell membrane. | 6 |
| 30552676 | 2019 | CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11. | 37 |
Citation
Dessen P
GNAI2 (G protein subunit alpha i2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40726/gnai2
