GPC4 (glypican 4)

2003-05-01  

Identity

HGNC
GPC4
LOCATION
Xq26.2
LOCUSID
2239
ALIAS
K-glypican,KPTS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2239
MIM: 300168
HGNC: 4452
Ensembl: ENSG00000076716

Variants:

dbSNP: 2239
ClinVar: 2239
TCGA: ENSG00000076716
COSMIC: GPC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076716ENST00000370828O75487

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective EXT1 causes exostoses 1, TRPS2 and CHDSREACTOMER-HSA-3656253
Defective EXT2 causes exostoses 2REACTOMER-HSA-3656237
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
HS-GAG biosynthesisREACTOMER-HSA-2022928
HS-GAG degradationREACTOMER-HSA-2024096
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384241232024Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.0
384241232024Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.0
375113532023The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis.0
378446822023Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure.0
375113532023The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis.0
378446822023Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure.0
352029592022Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients.4
359447702022Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease.2
352029592022Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients.4
359447702022Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease.2
321996122020Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation.13
321996122020Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation.13
309826112019Pathogenic Variants in GPC4 Cause Keipert Syndrome.13
312170572019Serum Glypican 4 Levels Are Associated with Metabolic Syndrome in a Han Population from Guizhou Province, China.4
314849222019CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.85

Citation

Dessen P

GPC4 (glypican 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40736