ADGRG2 (adhesion G protein-coupled receptor G2)

2003-05-01  

Identity

HGNC
ADGRG2
LOCATION
Xp22.13
LOCUSID
10149
ALIAS
CBAVDX,EDDM6,GPR64,HE6,TM7LN2

Other Information

Locus ID:

NCBI: 10149
MIM: 300572
HGNC: 4516
Ensembl: ENSG00000173698

Variants:

dbSNP: 10149
ClinVar: 10149
TCGA: ENSG00000173698
COSMIC: ADGRG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173698ENST00000340581Q8IZP9
ENSG00000173698ENST00000354791Q8IZP9
ENSG00000173698ENST00000356606Q8IZP9
ENSG00000173698ENST00000357544Q8IZP9
ENSG00000173698ENST00000357991Q8IZP9
ENSG00000173698ENST00000360279Q8IZP9
ENSG00000173698ENST00000379869Q8IZP9
ENSG00000173698ENST00000379873Q8IZP9
ENSG00000173698ENST00000379876Q8IZP9
ENSG00000173698ENST00000379878Q8IZP9

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372731652023A novel ADGRG2 truncating variant associated with X-linked obstructive azoospermia in a large Chinese pedigree.0
380693092023Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker.0
372731652023A novel ADGRG2 truncating variant associated with X-linked obstructive azoospermia in a large Chinese pedigree.0
380693092023Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker.0
359822272022Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms.5
359822272022Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms.5
342342542021Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2.2
342342542021Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2.2
318455232020Novel ADGRG2 truncating variants in patients with X-linked congenital absence of vas deferens.11
323141952020A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens.5
318455232020Novel ADGRG2 truncating variants in patients with X-linked congenital absence of vas deferens.11
323141952020A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens.5
314128162019G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer.6
315022832019Spatial regulation of GPR64/ADGRG2 signaling by β-arrestins and GPCR kinases.13
314128162019G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer.6

Citation

Dessen P

ADGRG2 (adhesion G protein-coupled receptor G2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40744/css/favicon/case-report-explorer/