GRID2 (glutamate ionotropic receptor delta type subunit 2)

2003-05-01  

Identity

HGNC
GRID2
LOCATION
4q22.1
LOCUSID
2895
ALIAS
GluD2,SCAR18
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2895
MIM: 602368
HGNC: 4576
Ensembl: ENSG00000152208

Variants:

dbSNP: 2895
ClinVar: 2895
TCGA: ENSG00000152208
COSMIC: GRID2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152208ENST00000282020O43424
ENSG00000152208ENST00000502699D6R9W8
ENSG00000152208ENST00000510992O43424
ENSG00000152208ENST00000512631D6R976
ENSG00000152208ENST00000513976H0YA12
ENSG00000152208ENST00000611049A0A087X043
ENSG00000152208ENST00000637838A0A1B0GW49

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Long-term depressionKEGGko04730
Neuroactive ligand-receptor interactionKEGGhsa04080
Long-term depressionKEGGhsa04730

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451257risperidoneChemicalClinicalAnnotationassociatedPD26905411

References

Pubmed IDYearTitleCitations
379440842024Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.1
379440842024Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.1
351592102022Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect.3
351592102022Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect.3
320650022021Association of Gene Variations in Ionotropic Glutamate Receptor and Attention-Deficit/Hyperactivity Disorder in the Chinese Population: A Two-Stage Case-Control Study.6
321706082021Autosomal recessive spinocerebellar ataxia 18 caused by homozygous exon 14 duplication in GRID2 and review of the literature.6
320650022021Association of Gene Variations in Ionotropic Glutamate Receptor and Attention-Deficit/Hyperactivity Disorder in the Chinese Population: A Two-Stage Case-Control Study.6
321706082021Autosomal recessive spinocerebellar ataxia 18 caused by homozygous exon 14 duplication in GRID2 and review of the literature.6
292079482017Homozygous GRID2 missense mutation predicts a shift in the D-serine binding domain of GluD2 in a case with generalized brain atrophy and unusual clinical features.13
292079482017Homozygous GRID2 missense mutation predicts a shift in the D-serine binding domain of GluD2 in a case with generalized brain atrophy and unusual clinical features.13
269054112016Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes.23
270190352016Potential of GRID2 receptor gene for preventing TNF-induced neurodegeneration in autism.9
269054112016Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes.23
270190352016Potential of GRID2 receptor gene for preventing TNF-induced neurodegeneration in autism.9
251221452015Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion.23

Citation

Dessen P

GRID2 (glutamate ionotropic receptor delta type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40753