Identity
HGNC
LOCATION
8p12
LOCUSID
ALIAS
GR,GSRD,HEL-75,HEL-S-122m
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2936
MIM: 138300
HGNC: 4623
Ensembl: ENSG00000104687
Variants:
dbSNP: 2936
ClinVar: 2936
TCGA: ENSG00000104687
COSMIC: GSR
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA150481189 | taxanes | Chemical | ClinicalAnnotation | associated | PD | 26194361 | |
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation | associated | PD | 26194361 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 26194361 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35361806 | 2022 | Identification, analysis of deleterious SNPs of the human GSR gene and their effects on the structure and functions of associated proteins and other diseases. | 3 |
| 35361806 | 2022 | Identification, analysis of deleterious SNPs of the human GSR gene and their effects on the structure and functions of associated proteins and other diseases. | 3 |
| 34090318 | 2021 | Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome. | 0 |
| 34107852 | 2021 | MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase. | 11 |
| 34090318 | 2021 | Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome. | 0 |
| 34107852 | 2021 | MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase. | 11 |
| 31530934 | 2020 | AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation. | 12 |
| 31530934 | 2020 | AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation. | 12 |
| 29105080 | 2018 | Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis. | 68 |
| 29105080 | 2018 | Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis. | 68 |
| 28693341 | 2017 | Effect of exercise intensity on Nrf2 signalling in young men. | 13 |
| 28693341 | 2017 | Effect of exercise intensity on Nrf2 signalling in young men. | 13 |
| 26316444 | 2016 | Plasma glutathione reductase activity and prognosis of septic shock. | 10 |
| 26316444 | 2016 | Plasma glutathione reductase activity and prognosis of septic shock. | 10 |
| 25645953 | 2015 | Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase. | 29 |
Citation
Dessen P
GSR (glutathione-disulfide reductase)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40763/gsr
