GSTA2 (glutathione S-transferase alpha 2)

2003-06-01  

Identity

HGNC
LOCATION
6p12.2
LOCUSID
ALIAS
GST2,GSTA2-2,GTA2,GTH2

Other Information

Locus ID:

NCBI: 2939
MIM: 138360
HGNC: 4627
Ensembl: ENSG00000244067

Variants:

dbSNP: 2939
ClinVar: 2939
TCGA: ENSG00000244067
COSMIC: GSTA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244067ENST00000493422P09210
ENSG00000244067ENST00000493422A0A140VKE2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240568162014Glutathione transferase-A2 S112T polymorphism predicts survival, transplant-related mortality, busulfan and bilirubin blood levels after allogeneic stem cell transplantation.11
240568162014Glutathione transferase-A2 S112T polymorphism predicts survival, transplant-related mortality, busulfan and bilirubin blood levels after allogeneic stem cell transplantation.11
236501892013Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.9
236501892013Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.9
211632592011The extended catalysis of glutathione transferase.4
217920762011Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer.12
218446552011Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients.2
211632592011The extended catalysis of glutathione transferase.4
217920762011Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer.12
218446552011Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients.2
198598032010No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk.13
198598032010No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk.13
200831222010Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.12
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37

Citation

Dessen P

GSTA2 (glutathione S-transferase alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40765/gsta2