Identity
HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
GST5,GSTB,GSTM3-3,GTM3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2947
MIM: 138390
HGNC: 4635
Ensembl: ENSG00000134202
Variants:
dbSNP: 2947
ClinVar: 2947
TCGA: ENSG00000134202
COSMIC: GSTM3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443340 | Anemia | Disease | VariantAnnotation | associated | PK | PD | 19786980 |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 19786980, 22188361 | |
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 19786980, 22188361 |
| PA445301 | Peripheral Nervous System Diseases | Disease | VariantAnnotation | associated | PK | PD | 19786980 |
| PA445846 | Thrombocytopenia | Disease | VariantAnnotation | associated | PK | PD | 19786980 |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 19786980, 22188361 |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 19786980, 22188361 |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | 23559402 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38228715 | 2024 | GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4. | 0 |
| 38228715 | 2024 | GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4. | 0 |
| 33121982 | 2021 | Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers. | 6 |
| 33482859 | 2021 | Low GSTM3 expression is associated with poor disease-free survival in resected esophageal squamous cell carcinoma. | 2 |
| 34209254 | 2021 | Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells. | 11 |
| 33121982 | 2021 | Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers. | 6 |
| 33482859 | 2021 | Low GSTM3 expression is associated with poor disease-free survival in resected esophageal squamous cell carcinoma. | 2 |
| 34209254 | 2021 | Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells. | 11 |
| 32645615 | 2020 | GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death. | 10 |
| 32645615 | 2020 | GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death. | 10 |
| 31172354 | 2019 | LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells. | 31 |
| 31172354 | 2019 | LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells. | 31 |
| 29569387 | 2018 | A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding. | 5 |
| 30054830 | 2018 | Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers tamoxifen resistance on breast cancer cells. | 9 |
| 29569387 | 2018 | A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding. | 5 |
Citation
Dessen P
GSTM3 (glutathione S-transferase mu 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40770/gstm3
