MOB2 (MOB kinase activator 2)

2003-02-01  

Identity

HGNC
MOB2
LOCATION
11p15.5
LOCUSID
81532
ALIAS
HCCA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81532
MIM: 611969
HGNC: 24904
Ensembl: ENSG00000182208

Variants:

dbSNP: 81532
ClinVar: 81532
TCGA: ENSG00000182208
COSMIC: MOB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182208ENST00000329957Q70IA6
ENSG00000182208ENST00000614710A0A087WVS8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
322862662020MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.35
322862662020MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.35
254600432015Regulation of DNA damage responses and cell cycle progression by hMOB2.22
257792242015Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.3
254600432015Regulation of DNA damage responses and cell cycle progression by hMOB2.22
257792242015Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.3
233261342012Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.1
233261342012Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.1
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.75
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206249132010Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.36
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206249132010Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.36
150670042004Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.45

Citation

Dessen P

MOB2 (MOB kinase activator 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40796