Identity
HGNC
LOCATION
20q11.21
LOCUSID
ALIAS
JTK9,p59Hck,p61Hck
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3055
MIM: 142370
HGNC: 4840
Ensembl: ENSG00000101336
Variants:
dbSNP: 3055
ClinVar: 3055
TCGA: ENSG00000101336
COSMIC: HCK
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37342066 | 2023 | HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling. | 1 |
| 37342066 | 2023 | HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling. | 1 |
| 35255496 | 2022 | A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas. | 2 |
| 35280440 | 2022 | HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia. | 6 |
| 35639855 | 2022 | Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK. | 14 |
| 35255496 | 2022 | A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas. | 2 |
| 35280440 | 2022 | HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia. | 6 |
| 35639855 | 2022 | Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK. | 14 |
| 32591642 | 2021 | Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma. | 10 |
| 33617879 | 2021 | Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative. | 3 |
| 33894273 | 2021 | miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK. | 6 |
| 34167558 | 2021 | HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML. | 4 |
| 32591642 | 2021 | Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma. | 10 |
| 33617879 | 2021 | Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative. | 3 |
| 33894273 | 2021 | miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK. | 6 |
Citation
Dessen P
HCK (HCK proto-oncogene, Src family tyrosine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40798/hck
