HMG20B (high mobility group 20B)

2003-02-01  

Identity

HGNC
HMG20B
LOCATION
19p13.3
LOCUSID
10362
ALIAS
BRAF25,BRAF35,HMGX2,HMGXB2,PP7706,SMARCE1r,SOXL,pp8857
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10362
MIM: 605535
HGNC: 5002
Ensembl: ENSG00000064961

Variants:

dbSNP: 10362
ClinVar: 10362
TCGA: ENSG00000064961
COSMIC: HMG20B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064961ENST00000262949B5MDG7
ENSG00000064961ENST00000333651Q9P0W2
ENSG00000064961ENST00000416526C9J8X5
ENSG00000064961ENST00000417382C9K049
ENSG00000064961ENST00000435022F8WES5
ENSG00000064961ENST00000453933C9JQA7
ENSG00000064961ENST00000585900K7EJR8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361712712022HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block.2
361712712022HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block.2
287606572017The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35.5
287606572017The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35.5
254861962014A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.1
254861962014A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.1
225705002012Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex.42
225705002012Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex.42
213996662011A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.17
213996662011A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.17
205304872010The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.17
205304872010The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.17
179611342007Expression of SoxE and SoxD genes in human gliomas.27
179611342007Expression of SoxE and SoxD genes in human gliomas.27
128095542003Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35.12

Citation

Dessen P

HMG20B (high mobility group 20B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40833/favicon/css/lib/case-report-explorer/