HMMR (hyaluronan mediated motility receptor)

2003-02-01  

Identity

HGNC
HMMR
LOCATION
5q34
LOCUSID
3161
ALIAS
CD168,IHABP,RHAMM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3161
MIM: 600936
HGNC: 5012
Ensembl: ENSG00000072571

Variants:

dbSNP: 3161
ClinVar: 3161
TCGA: ENSG00000072571
COSMIC: HMMR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072571ENST00000353866O75330
ENSG00000072571ENST00000358715O75330
ENSG00000072571ENST00000393915O75330
ENSG00000072571ENST00000432118O75330
ENSG00000072571ENST00000520345E5RI30
ENSG00000072571ENST00000522094E5RIH2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ECM-receptor interactionKEGGko04512
ECM-receptor interactionKEGGhsa04512
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan uptake and degradationREACTOMER-HSA-2160916
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA445113NeutropeniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
386332472024Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in hepatocellular carcinoma.1
386332472024Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in hepatocellular carcinoma.1
362076082023The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles.4
366033702023Tumor-promoting roles of HMMR in lung adenocarcinoma.1
369451142023RHAMM marks proliferative subpopulation of human colorectal cancer stem cells.4
371863002023Receptor for hyaluronan-mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients.2
376739612023Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer.1
362076082023The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles.4
366033702023Tumor-promoting roles of HMMR in lung adenocarcinoma.1
369451142023RHAMM marks proliferative subpopulation of human colorectal cancer stem cells.4
371863002023Receptor for hyaluronan-mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients.2
376739612023Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer.1
355770442022RHAMM expression tunes the response of breast cancer cell lines to hyaluronan.3
355770442022RHAMM expression tunes the response of breast cancer cell lines to hyaluronan.3
323116972021CD44 and RHAMM expression patterns in the human developing lung.4

Citation

Dessen P

HMMR (hyaluronan mediated motility receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40837