HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2)

2003-11-01  

Identity

HGNC
LOCATION
16q23.3
LOCUSID
ALIAS
EDH17B2,HSD17,SDR9C2
FUSION GENES

Other Information

Locus ID:

NCBI: 3294
MIM: 109685
HGNC: 5211
Ensembl: ENSG00000086696

Variants:

dbSNP: 3294
ClinVar: 3294
TCGA: ENSG00000086696
COSMIC: HSD17B2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086696ENST00000199936P37059
ENSG00000086696ENST00000563491H3BQY3
ENSG00000086696ENST00000566213H3BV42
ENSG00000086696ENST00000566838H3BRZ6
ENSG00000086696ENST00000568090H3BS44
ENSG00000086696ENST00000569351H3BNN1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
Metabolic pathwaysKEGGhsa01100
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Estrogen biosynthesisREACTOMER-HSA-193144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
372444452023Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.1
372444452023Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.1
355108722022A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.3
355108722022A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.3
332461542021Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.2
332461542021Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.2
302282092019Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression.23
302282092019Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression.23
257764742015Expression of 17β-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer.4
259298102015The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy.23
261235902015Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2.2
261945042015Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH.3
262282492015Retinoic acid has the potential to suppress endometriosis development.8
263232332015Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women.2
257764742015Expression of 17β-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer.4

Citation

Dessen P

HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40868/hsd17b2