HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7)

2003-06-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
PRAP,SDR37C1

Other Information

Locus ID:

NCBI: 51478
MIM: 606756
HGNC: 5215
Ensembl: ENSG00000132196

Variants:

dbSNP: 51478
ClinVar: 51478
TCGA: ENSG00000132196
COSMIC: HSD17B7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132196ENST00000254521P56937
ENSG00000132196ENST00000254521A0A024R913
ENSG00000132196ENST00000367915Q5T249
ENSG00000132196ENST00000466176F2Z2C2
ENSG00000132196ENST00000470195V9GYN3

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid hormone biosynthesisKEGGko00140
Steroid biosynthesisKEGGhsa00100
Steroid hormone biosynthesisKEGGhsa00140
Metabolic pathwaysKEGGhsa01100
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterolKEGGhsa_M00101
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterolKEGGM00101
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
341853802021HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations.7
341853802021HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations.7
302272432019The dual sex hormone specificity for human reductive 17β-hydroxysteroid dehydrogenase type 7: Synergistic function in estrogen and androgen control.2
312073612019Mutual regulations and breast cancer cell control by steroidogenic enzymes: Dual sex-hormone receptor modulation upon 17β-HSD7 inhibition.0
302272432019The dual sex hormone specificity for human reductive 17β-hydroxysteroid dehydrogenase type 7: Synergistic function in estrogen and androgen control.2
312073612019Mutual regulations and breast cancer cell control by steroidogenic enzymes: Dual sex-hormone receptor modulation upon 17β-HSD7 inhibition.0
285547252017Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown.0
286455272017Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.4
285547252017Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown.0
286455272017Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.4
252578172015Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.9
259669042015Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.6
252578172015Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.9
259669042015Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.6
233006272012Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression.6

Citation

Dessen P

HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40869/hsd17b7