HSPA1A (heat shock protein family A (Hsp70) member 1A)

2003-08-01 Affiliation

Identity

HGNC

HSPA1A

LOCATION

6p21.33

LOCUSID

3303

ALIAS

HEL-S-103,HSP70-1,HSP70-1A,HSP70-2,HSP70.1,HSP70.2,HSP70I,HSP72,HSPA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3303
MIM: 140550
HGNC: 5232
Ensembl: ENSG00000204389

Variants:

dbSNP: 3303
ClinVar: 3303
TCGA: ENSG00000204389
COSMIC: HSPA1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204389	ENST00000375651	P0DMV8
ENSG00000204389	ENST00000375651	A8K5I0
ENSG00000204389	ENST00000608703	V9GZ37

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Antigen processing and presentation	KEGG	ko04612
MAPK signaling pathway	KEGG	hsa04010
Antigen processing and presentation	KEGG	hsa04612
Prion diseases	KEGG	ko05020
Prion diseases	KEGG	hsa05020
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Spliceosome, Prp19/CDC5L complex	KEGG	hsa_M00353
Spliceosome, 35S U5-snRNP	KEGG	hsa_M00355
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Spliceosome, Prp19/CDC5L complex	KEGG	M00353
Spliceosome, 35S U5-snRNP	KEGG	M00355
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Export of Viral Ribonucleoproteins from Nucleus	REACTOME	R-HSA-168274
Viral RNP Complexes in the Host Cell Nucleus	REACTOME	R-HSA-168330
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Gene Expression	REACTOME	R-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Attenuation phase	REACTOME	R-HSA-3371568
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448785	carbamazepine	Chemical	ClinicalAnnotation	associated		PD	16538175

References

Pubmed ID	Year	Title	Citations
38703814	2024	Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors.	0
38703814	2024	Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors.	0
36345598	2023	Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.	1
36519896	2023	Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA.	1
36814356	2023	Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn's Disease.	1
37254218	2023	ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.	2
37298493	2023	Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions.	0
37525035	2023	A Genomic Study of the Japanese Population Focusing on the Glucocorticoid Receptor Interactome Highlights Distinct Genetic Characteristics Associated with Stress Response.	0
37926404	2023	Association of elevated extracellular HSP72 in albuminuria with systemic inflammation and disease progression in type 2 diabetic kidney disease.	0
36345598	2023	Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.	1
36519896	2023	Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA.	1
36814356	2023	Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn's Disease.	1
37254218	2023	ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.	2
37298493	2023	Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions.	0
37525035	2023	A Genomic Study of the Japanese Population Focusing on the Glucocorticoid Receptor Interactome Highlights Distinct Genetic Characteristics Associated with Stress Response.	0

Citation

Dessen P

HSPA1A (heat shock protein family A (Hsp70) member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40871