HSPA2 (heat shock protein family A (Hsp70) member 2)

2003-08-01  

Identity

HGNC
LOCATION
14q23.3
LOCUSID
ALIAS
HSP70-2,HSP70-3
FUSION GENES

Other Information

Locus ID:

NCBI: 3306
MIM: 140560
HGNC: 5235
Ensembl: ENSG00000126803

Variants:

dbSNP: 3306
ClinVar: 3306
TCGA: ENSG00000126803
COSMIC: HSPA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126803ENST00000247207P54652
ENSG00000126803ENST00000247207A0A024R6B5
ENSG00000126803ENST00000394709P54652
ENSG00000126803ENST00000394709A0A024R6B5

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Antigen processing and presentationKEGGko04612
MAPK signaling pathwayKEGGhsa04010
Antigen processing and presentationKEGGhsa04612
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386411792024The human testis-enriched HSPA2 interacts with HIF-1α in epidermal keratinocytes, yet HIF-1α stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity.0
386411792024The human testis-enriched HSPA2 interacts with HIF-1α in epidermal keratinocytes, yet HIF-1α stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity.0
348456422022Paternal factors in recurrent pregnancy loss: an insight through analysis of non-synonymous single-nucleotide polymorphism in human testis-specific chaperone HSPA2 gene.4
349591942022Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status.7
356490692022Tumorigenic and immunological roles of Heat shock protein A2 in pancreatic cancer: a bioinformatics analysis.0
362465622022HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for Prognosis among HSP70 Family in Alzheimer's Disease.9
348456422022Paternal factors in recurrent pregnancy loss: an insight through analysis of non-synonymous single-nucleotide polymorphism in human testis-specific chaperone HSPA2 gene.4
349591942022Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status.7
356490692022Tumorigenic and immunological roles of Heat shock protein A2 in pancreatic cancer: a bioinformatics analysis.0
362465622022HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for Prognosis among HSP70 Family in Alzheimer's Disease.9
332462762021Human sperm chaperone HSPA2 distribution during in vitro capacitation.7
344800882021Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease.19
332462762021Human sperm chaperone HSPA2 distribution during in vitro capacitation.7
344800882021Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease.19
304634552020Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection.2

Citation

Dessen P

HSPA2 (heat shock protein family A (Hsp70) member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40874/hspa2