HSPA4 (heat shock protein family A (Hsp70) member 4)

2003-06-01  

Identity

HGNC
HSPA4
LOCATION
5q31.1
LOCUSID
3308
ALIAS
APG-2,HEL-S-5a,HS24/P52,HSPH2,RY,hsp70,hsp70RY
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3308
MIM: 601113
HGNC: 5237
Ensembl: ENSG00000170606

Variants:

dbSNP: 3308
ClinVar: 3308
TCGA: ENSG00000170606
COSMIC: HSPA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170606ENST00000304858P34932
ENSG00000170606ENST00000615899A0A087WTS8
ENSG00000170606ENST00000617074A0A087WYC1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Antigen processing and presentationKEGGko04612
Tight junctionKEGGhsa04530
Antigen processing and presentationKEGGhsa04612
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373395212024HSPA4 regulated glioma progression via activation of AKT signaling pathway.1
379306172024Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people.0
382666412024HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III.2
385973272024Dynamically changed HSP70 after reperfusion following cerebral infarction in human and rats: correlation with p38 MAPK.0
373395212024HSPA4 regulated glioma progression via activation of AKT signaling pathway.1
379306172024Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people.0
382666412024HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III.2
385973272024Dynamically changed HSP70 after reperfusion following cerebral infarction in human and rats: correlation with p38 MAPK.0
368306412023HSP70 and Primary Arterial Hypertension.4
368332812023HSP70 Expression Signature in Renal Cell Carcinoma: A Clinical and Bioinformatic Analysis Approach.1
369314922023HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection.0
369878112023SATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction.0
373906452023The multifunction of HSP70 in cancer: Guardian or traitor to the survival of tumor cells and the next potential therapeutic target.7
374180852023HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma.2
379324712023A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase.0

Citation

Dessen P

HSPA4 (heat shock protein family A (Hsp70) member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40875