HSPA9 (heat shock protein family A (Hsp70) member 9)

2003-02-01  

Identity

HGNC
HSPA9
LOCATION
5q31.2
LOCUSID
3313
ALIAS
CRP40,CSA,EVPLS,GRP-75,GRP75,HEL-S-124m,HSPA9B,MOT,MOT2,MTHSP75,PBP74,SAAN,SIDBA4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3313
MIM: 600548
HGNC: 5244
Ensembl: ENSG00000113013

Variants:

dbSNP: 3313
ClinVar: 3313
TCGA: ENSG00000113013
COSMIC: HSPA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113013ENST00000297185P38646
ENSG00000113013ENST00000297185A0A384P5G6
ENSG00000113013ENST00000501917A0A3B3ITN1
ENSG00000113013ENST00000504810D6RJI2
ENSG00000113013ENST00000504902H0Y8K0
ENSG00000113013ENST00000505110D6RDH7
ENSG00000113013ENST00000507115D6RCD7
ENSG00000113013ENST00000507886D6RA73
ENSG00000113013ENST00000512328H0Y8S0
ENSG00000113013ENST00000523929H0YBG6
ENSG00000113013ENST00000649578A0A3B3ITI4

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382532182024METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer.1
382816622024Prenatal to preimplantation genetic diagnosis of a novel compound heterozygous mutation in HSPA9 associated with Even-Plus syndrome.0
385084442024HSPA9/mortalin inhibition disrupts erythroid maturation through a TP53-dependent mechanism in human CD34+ hematopoietic progenitor cells.2
386048142024OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape.0
382532182024METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer.1
382816622024Prenatal to preimplantation genetic diagnosis of a novel compound heterozygous mutation in HSPA9 associated with Even-Plus syndrome.0
385084442024HSPA9/mortalin inhibition disrupts erythroid maturation through a TP53-dependent mechanism in human CD34+ hematopoietic progenitor cells.2
386048142024OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape.0
368998362023Clinical Relevance of Mortalin in Ovarian Cancer Patients.2
376408052023The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway.0
368998362023Clinical Relevance of Mortalin in Ovarian Cancer Patients.2
376408052023The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway.0
347171912022Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.3
347965242022Expressions of HSPA1L and HSPA9 are associated with poor sperm quality of low-motility spermatozoa in fertile men.3
355419012022GRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer Patients.15

Citation

Dessen P

HSPA9 (heat shock protein family A (Hsp70) member 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40879