HSPB2 (heat shock protein family B (small) member 2)

2003-02-01  

Identity

HGNC
HSPB2
LOCATION
11q23.1
LOCUSID
3316
ALIAS
HSP27,Hs.78846,LOH11CR1K,MKBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3316
MIM: 602179
HGNC: 5247
Ensembl: ENSG00000170276

Variants:

dbSNP: 3316
ClinVar: 3316
TCGA: ENSG00000170276
COSMIC: HSPB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170276ENST00000304298Q16082

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205

References

Pubmed IDYearTitleCitations
367689272023Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.0
369314922023HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection.0
376060392023HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.3
377977962023Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.2
367689272023Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.0
369314922023HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection.0
376060392023HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.3
377977962023Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.2
316920312020Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6.14
323152832020HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.7
316920312020Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6.14
323152832020HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.7
310885772019Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas.9
310885772019Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas.9
281811532017An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.12

Citation

Dessen P

HSPB2 (heat shock protein family B (small) member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40881/js/lib/deep-insight-explorer/tumors-explorer/