ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor)

2008-07-01   Masakazu Yashiro 

The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan





ICAM1 gene maps on chromosome 19p13.3-p13.2 scanning 15512 bp.


7 exon; mRNA 3249 bp.



A transmembrane glycoprotein of 532 amino acids, which has a molecular mass ranging from 75 to 115 kDa. ICAM-1 is a member of the immunoglobulin supergenge family, and contains five extracellular immunoglobulin-like domains.


ICAM-1 is expressed on various cells of both hematopoietic and non-hematopoietic cells, including endothelial cells, leukocytes other than basophilic granulocytes, T cells, B cells, fibroblasts, and cancer cells.


ICAM-1, a member of adhesion molecules, binds to two integrins belonging to the beta2 subfamily CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on the surface of leukocytes. ICAM1 is a key molecule in immune-mediated and inflammatory processes and function as a co-stimulatory signal which is important for the trans-endothelial migration of leukocytes and the activation of T cells. ICAM-1 can be induced under inflammatory condition by TNF-alpha in a process that involves IKK-beta. ICAM1 on target cells leads to recruitment of the MHC-I proteins to the contact area and enhances presentation of cognate peptide MHC-I complex to cytotoxic T cells. ICAM-1 interacts with important factors involved in many kinds of human cancers. ICAM-1 is involved in transmembrane signal transduction in the regulatory process of cell proliferation through the mitogen-activated protein kinase (MAPK) pathway and eventually the AP-1 pathway (Springer, 1990; Dustin et al., 1998; Simmons et al., 1988; Caras et al., 1987; Rothlein et al., 1986; Dustin et al., 1986; Tsujisaki et al., 1991; Gardiner et DSouza, 1999).

Implicated in

Entity name
ICAM-1 expresses with a dose- and time-dependent increase in human malignant melanoma cells on stimulation of TNF-alpha. Inhibition of ICAM-1 expression on melanoma cells reduces the metastatic ability of the melanoma cells, indicating an important role of ICAM-1 in metastasis (Miele et al., 1994).
Entity name
Hepatocellular carcinoma
Serum concentration of ICAM-1 (sICAM-1) in patients with hepatocellular carcinoma is a marker for disease progression and prognosis. Higher sICAM-1 levels are more frequently observed in those patients with multiple lesions and intra-hepatic metastasis (Mei et al., 2000).
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Prostate cancer
Two polymorphisms and a common haplotype within the ICAM-1 gene cluster were correlated with prostate cancer risk among men with family history of the disease (Chen et al., 2006).
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Colon cancer
ICAM-1 expression is decreased in colorectal cancer (Berndt et al., 2008).
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Gastric cancer
Decreased ICAM expression leads to lymph node metastasis, suggesting that ICAM-1 gene transfection can inhibit lymph node metastasis (Tanaka et al., 2002; Yashiro et al., 2005).
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Head and neck cancer
sICAM-1 shows a significant elevation in the sera of patients with nasopharyngeal carcinoma compared to healthy controls (Liu et al., 1999).
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A high expression of ICAM-1 may identify high-risk MDS (Graf et al., 2005).
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Breast Cancer
ICAM-1 down-regulation at the mRNA and protein levels led to a suppression of breast cells invasion (Rosette et al., 2005).


Pubmed IDLast YearTitleAuthors
182454902008Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer.Berndt U et al
24335961987Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins.Caras IW et al
167337122006ICAM gene cluster SNPs and prostate cancer risk in African Americans.Chen H et al
30864511986Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).Dustin ML et al
30764181988Supergene families meet in the immune system.Dustin ML et al
102070141999Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis.Gardiner EE et al
155926722005High expression of costimulatory molecules correlates with low relapse-free survival probability in acute myeloid leukemia (AML).Graf M et al
98884811999Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer.Liu CM et al
118196112000Clinical significance of serum intercellular adhesion molecule-1 detection in patients with hepatocellular carcinoma.Mei MH et al
79159921994Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides.Miele ME et al
157744882005Role of ICAM1 in invasion of human breast cancer cells.Rosette C et al
35256751986A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.Rothlein R et al
33402131988ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.Simmons D et al
19740321990Adhesion receptors of the immune system.Springer TA et al
123733022002Lipid-mediated gene transfection of intercellular adhesion molecule-1 suppresses the peritoneal metastasis of gastric carcinoma.Tanaka H et al
17126831991Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.Tsujisaki M et al
164161662005CD54 expression is predictive for lymphatic spread in human gastric carcinoma.Yashiro M et al

Other Information

Locus ID:

NCBI: 3383
MIM: 147840
HGNC: 5344
Ensembl: ENSG00000090339


dbSNP: 3383
ClinVar: 3383
TCGA: ENSG00000090339


Gene IDTranscript IDUniprot

Expression (GTEx)



PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Natural killer cell mediated cytotoxicityKEGGko04650
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Natural killer cell mediated cytotoxicityKEGGhsa04650
Leukocyte transendothelial migrationKEGGhsa04670
Viral myocarditisKEGGhsa05416
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Signaling by InterleukinsREACTOMER-HSA-449147
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected


Pubmed IDYearTitleCitations
120820812002Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.159
205115482010Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.155
177858442007ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.134
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
245769472014HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells.120
199490842010Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation.119
164291282006Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains.118
171167322006An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.117
186042672008Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.105
186042672008Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.105


Masakazu Yashiro

ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/40909/icam1id40909ch19p13