ID3 (inhibitor of DNA binding 3, HLH protein)

2003-02-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
HEIR-1,bHLHb25
FUSION GENES

Other Information

Locus ID:

NCBI: 3399
MIM: 600277
HGNC: 5362
Ensembl: ENSG00000117318

Variants:

dbSNP: 3399
ClinVar: 3399
TCGA: ENSG00000117318
COSMIC: ID3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117318ENST00000374561Q02535

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
231435952012Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.124
226984032012ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21.85
246556512014Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.73
166824352006Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome.51
219759322011EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction.51
237718842013Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells.28
211910652011Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway.27
154945332004Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells.25
201913792010Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells.25
201857982010Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans.24

Citation

Dessen P

ID3 (inhibitor of DNA binding 3, HLH protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40915/gc-id3