IFNAR2 (interferon alpha and beta receptor subunit 2)

2003-11-01  

Identity

HGNC
IFNAR2
LOCATION
21q22.11
LOCUSID
3455
ALIAS
IFN-R,IFN-alpha-REC,IFNABR,IFNARB,IMD45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3455
MIM: 602376
HGNC: 5433
Ensembl: ENSG00000249624

Variants:

dbSNP: 3455
ClinVar: 3455
TCGA: ENSG00000249624
COSMIC: IFNAR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000249624ENST00000432231H7C3V1
ENSG00000249624ENST00000433395H0Y3Z8

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Jak-STAT signaling pathwayKEGGko04630
Natural killer cell mediated cytotoxicityKEGGko04650
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Jak-STAT signaling pathwayKEGGhsa04630
Natural killer cell mediated cytotoxicityKEGGhsa04650
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694

References

Pubmed IDYearTitleCitations
369274552023Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19.3
370284392023Association of IFNAR1 and IFNAR2 with COVID-19 severity.3
369274552023Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19.3
370284392023Association of IFNAR1 and IFNAR2 with COVID-19 severity.3
343556762022Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach.8
350818722022Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2.8
354424172022Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.26
359673492022IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19.14
364391152022Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia.1
366727702022Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.12
343556762022Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach.8
350818722022Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2.8
354424172022Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.26
359673492022IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19.14
364391152022Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia.1

Citation

Dessen P

IFNAR2 (interferon alpha and beta receptor subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40923/tumors-explorer/teaching-explorer/