IFNGR1 (interferon gamma receptor 1)

2003-11-01 Affiliation

Identity

HGNC

IFNGR1

LOCATION

6q23.3

LOCUSID

3459

ALIAS

CD119,IFNGR,IMD27A,IMD27B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3459
MIM: 107470
HGNC: 5439
Ensembl: ENSG00000027697

Variants:

dbSNP: 3459
ClinVar: 3459
TCGA: ENSG00000027697
COSMIC: IFNGR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000027697	ENST00000367739	P15260
ENSG00000027697	ENST00000367739	A0A0S2Z3Y2
ENSG00000027697	ENST00000414770	Q5TFD1
ENSG00000027697	ENST00000458076	Q5TFC9
ENSG00000027697	ENST00000642390	A0A2R8Y7R1
ENSG00000027697	ENST00000643119	A0A2R8Y792
ENSG00000027697	ENST00000644894	A0A2R8YFL3
ENSG00000027697	ENST00000645045	A0A2R8YEN6
ENSG00000027697	ENST00000645753	A0A2R8YFL3
ENSG00000027697	ENST00000646036	A0A2R8Y4U4
ENSG00000027697	ENST00000646898	A0A2R8Y4U4
ENSG00000027697	ENST00000647124	A0A2R8YFL3

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
HIF-1 signaling pathway	KEGG	hsa04066
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Regulation of IFNG signaling	REACTOME	R-HSA-877312
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37213666	2023	Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells.	0
37327531	2023	Single nucleotide polymorphism rs2234711 of interferon gamma receptor 1 is associated with pulmonary tuberculosis in the population of North India.	1
37213666	2023	Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells.	0
37327531	2023	Single nucleotide polymorphism rs2234711 of interferon gamma receptor 1 is associated with pulmonary tuberculosis in the population of North India.	1
35074548	2022	Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guérin osteomyelitis.	0
35918221	2022	Genetic Variations in IFNGR1, BDNF and IL-10 May Predict the Susceptibility to Depression and Anxiety in Chinese Women With Breast Cancer.	5
36148347	2022	Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis.	2
36260452	2022	Correlation of single-nucleotide polymorphism at interferon-gamma R1 (at Position - 56) in positive purified protein derivative health workers with COVID-19 infection.	1
36524496	2022	IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study.	0
35074548	2022	Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guérin osteomyelitis.	0
35918221	2022	Genetic Variations in IFNGR1, BDNF and IL-10 May Predict the Susceptibility to Depression and Anxiety in Chinese Women With Breast Cancer.	5
36148347	2022	Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis.	2
36260452	2022	Correlation of single-nucleotide polymorphism at interferon-gamma R1 (at Position - 56) in positive purified protein derivative health workers with COVID-19 infection.	1
36524496	2022	IFNG and IFNGR1 polymorphisms are associated with tuberculosis: a case-control study.	0
33393726	2021	Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet's Disease.	12

Citation

Dessen P

IFNGR1 (interferon gamma receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40926