IL15 (interleukin 15)

2003-11-01  

Identity

HGNC
IL15
LOCATION
4q31.21
LOCUSID
3600
ALIAS
IL-15
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3600
MIM: 600554
HGNC: 5977
Ensembl: ENSG00000164136

Variants:

dbSNP: 3600
ClinVar: 3600
TCGA: ENSG00000164136
COSMIC: IL15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164136ENST00000296545P40933
ENSG00000164136ENST00000320650P40933
ENSG00000164136ENST00000394159P40933
ENSG00000164136ENST00000477265P40933
ENSG00000164136ENST00000514653P40933
ENSG00000164136ENST00000529613P40933

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378024672024Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.1
384469002024Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies.0
385819152024Interleukin-15 is a hair follicle immune privilege guardian.0
388142402024IL-15 gene mutation as a molecular risk factor in acute lymphoid leukemia.0
378024672024Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.1
384469002024Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies.0
385819152024Interleukin-15 is a hair follicle immune privilege guardian.0
388142402024IL-15 gene mutation as a molecular risk factor in acute lymphoid leukemia.0
366518452023Counteracting Interleukin-15 to Elucidate Its Modes of Action in Physiology and Pathology.4
371057152023Myc controls NK cell development, IL-15-driven expansion, and translational machinery.3
371536032023The role of interleukin-15 in the development and treatment of hematological malignancies.5
373343562023The roles of different forms of IL-15 in human melanoma progression.1
378073372023Investigating the interplay of hematological parameters, CD markers, genetic polymorphisms, and database mutations in the IL15 gene in acute myeloid leukemia patients.0
366518452023Counteracting Interleukin-15 to Elucidate Its Modes of Action in Physiology and Pathology.4
371057152023Myc controls NK cell development, IL-15-driven expansion, and translational machinery.3

Citation

Dessen P

IL15 (interleukin 15)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40943