IL17C (interleukin 17C)

2003-06-01 Affiliation

Identity

HGNC

IL17C

LOCATION

16q24.2

LOCUSID

27189

ALIAS

CX2,IL-17C

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27189
MIM: 604628
HGNC: 5983
Ensembl: ENSG00000124391

Variants:

dbSNP: 27189
ClinVar: 27189
TCGA: ENSG00000124391
COSMIC: IL17C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124391	ENST00000244241	Q9P0M4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-17 signaling	REACTOME	R-HSA-448424
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38704381	2024	IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.	0
38704381	2024	IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.	0
37263138	2023	IL-17C neutralization protects the kidney against acute injury and chronic injury.	1
37263138	2023	IL-17C neutralization protects the kidney against acute injury and chronic injury.	1
35479098	2022	Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.	19
36130829	2022	Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.	1
35479098	2022	Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.	19
36130829	2022	Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.	1
33411748	2021	IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.	10
33411748	2021	IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.	10
32174926	2020	IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.	33
32232015	2020	Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.	9
33162788	2020	IL-17C expression and its correlation with pediatric adenoids: a preliminary study.	0
32174926	2020	IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.	33
32232015	2020	Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.	9

Citation

Dessen P

IL17C (interleukin 17C)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40946