IL6ST (interleukin 6 cytokine family signal transducer)

2003-08-01  

Identity

HGNC
IL6ST
LOCATION
5q11.2
LOCUSID
3572
ALIAS
CD130,CDW130,GP130,HIES4,IL-6RB,sGP130
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3572
MIM: 600694
HGNC: 6021
Ensembl: ENSG00000134352

Variants:

dbSNP: 3572
ClinVar: 3572
TCGA: ENSG00000134352
COSMIC: IL6ST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134352ENST00000336909P40189
ENSG00000134352ENST00000381286Q5FC02
ENSG00000134352ENST00000381287P40189
ENSG00000134352ENST00000381293Q5FC05
ENSG00000134352ENST00000381294P40189
ENSG00000134352ENST00000381294A0A0A0N0L2
ENSG00000134352ENST00000381298P40189
ENSG00000134352ENST00000396816Q5FC07
ENSG00000134352ENST00000502326P40189
ENSG00000134352ENST00000503773D6RH03
ENSG00000134352ENST00000522633P40189
ENSG00000134352ENST00000651614A0A494BZU0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 signalingREACTOMER-HSA-1059683
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK1 (ERK2) activationREACTOMER-HSA-112411
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384539152024Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.0
385785682024An Indian Family with Autosomal Dominant Hyper-IgE Syndrome Due to IL6ST Defect.0
386152362024Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris.0
384539152024Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.0
385785682024An Indian Family with Autosomal Dominant Hyper-IgE Syndrome Due to IL6ST Defect.0
386152362024Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris.0
354358042023Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells.12
365658972023Variation in IL6ST cytokine family function and the potential of IL6 trans-signalling in ERα positive breast cancer cells.1
370989862023Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease.2
372432822023Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population.2
378204522023Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex.0
378285132023Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.0
378801582023Mononuclear cells from patients with rhupus are influenced by TNF in their production of gp130/sIL-6Rb and APRIL.0
381338792023The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.1
354358042023Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells.12

Citation

Dessen P

IL6ST (interleukin 6 cytokine family signal transducer)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40964/tumors-explorer/tumors-explorer/css/template-card.css