Identity
HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
IMPD2,IMPDH-II
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3615
MIM: 146691
HGNC: 6053
Ensembl: ENSG00000178035
Variants:
dbSNP: 3615
ClinVar: 3615
TCGA: ENSG00000178035
COSMIC: IMPDH2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178035 | ENST00000326739 | P12268 |
| ENSG00000178035 | ENST00000326739 | A0A384N6C2 |
| ENSG00000178035 | ENST00000429182 | H0Y4R1 |
| ENSG00000178035 | ENST00000442157 | E7ETK5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748728 | mycophenolic acid | Chemical | ClinicalAnnotation, Pathway | associated | PD | 18444945, 19617864, 19770842, 20679962, 21996196, 22960765, 24220207 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 18444945, 19617864, 19770842, 20679962, 21996196, 22960765 | |
| PA449167 | cyclosporine | Chemical | ClinicalAnnotation | associated | PD | 18444945, 19617864, 19770842, 21996196, 22960765 | |
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PD | 18444945, 19617864, 19770842, 20679962, 21996196, 22960765 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38310229 | 2024 | Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer. | 0 |
| 38310229 | 2024 | Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer. | 0 |
| 36629054 | 2023 | c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming. | 6 |
| 36648520 | 2023 | Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population. | 1 |
| 36657279 | 2023 | Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia. | 0 |
| 37414152 | 2023 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. | 1 |
| 37907047 | 2023 | Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway. | 1 |
| 36629054 | 2023 | c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming. | 6 |
| 36648520 | 2023 | Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population. | 1 |
| 36657279 | 2023 | Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia. | 0 |
| 37414152 | 2023 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. | 1 |
| 37907047 | 2023 | Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway. | 1 |
| 34673127 | 2022 | Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer. | 9 |
| 35484884 | 2022 | Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation. | 0 |
| 36177032 | 2022 | SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling. | 6 |
Citation
Dessen P
IMPDH2 (inosine monophosphate dehydrogenase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40972/impdh2
