Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3643
MIM: 147670
HGNC: 6091
Ensembl: ENSG00000171105
Variants:
dbSNP: 3643
ClinVar: 3643
TCGA: ENSG00000171105
COSMIC: INSR
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171105 | ENST00000302850 | P06213 |
| ENSG00000171105 | ENST00000341500 | P06213 |
| ENSG00000171105 | ENST00000600492 | M0R3E6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA445113 | Neutropenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451728 | topiramate | Chemical | ClinicalAnnotation | associated | PD | 26524290 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38521788 | 2024 | Activation of the insulin receptor by insulin-like growth factor 2. | 0 |
| 38752921 | 2024 | The brain insulin receptor gene network and associations with frailty index. | 0 |
| 38521788 | 2024 | Activation of the insulin receptor by insulin-like growth factor 2. | 0 |
| 38752921 | 2024 | The brain insulin receptor gene network and associations with frailty index. | 0 |
| 36408724 | 2023 | Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes. | 0 |
| 36548088 | 2023 | Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. | 5 |
| 36599833 | 2023 | Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. | 5 |
| 36739671 | 2023 | Insulin receptor-inspired soluble insulin binder. | 0 |
| 36931226 | 2023 | Associations between heredity, height, BMI, diabetes mellitus type 1 or 2 and gene variants in the insulin receptor (INSR) gene in patients with schizophrenia. | 1 |
| 37001136 | 2023 | The Activation Mechanism of the Insulin Receptor: A Structural Perspective. | 13 |
| 37052755 | 2023 | Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. | 5 |
| 37595266 | 2023 | Insulin Signaling Through the Insulin Receptor Increases Linear Growth Through Effects on Bone and the GH-IGF-1 Axis. | 2 |
| 37717597 | 2023 | Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene? | 0 |
| 37724583 | 2023 | The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1. | 1 |
| 37863470 | 2023 | Association between diabetes and stress-induced hyperglycemia with skeletal muscle gene expression of INSR in critically ill patients: A prospective cohort study. | 0 |
Citation
Dessen P
INSR (insulin receptor)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/40986/insr
